Part 1: Electro-acupincture influence inflammation induced pain memory via cAMP/PKA/CREB pathway in the Anterior Cingulate Cortex.
Our precious studies demonstrate that inflammation indused pai memory can be indeed caused by reapeated injections in rats. EA stimulation could influence pain memory by delaying the awaken time of pain memory and reduceing the intensity of pain. The pain memory and its retrival are related to the increase of p-CREB and co-location of p-CREB with GFAP, OX-42-, or neuN-positive cells in ACC. The proper mechanism of EA on pain Memory is that EA could inhibit the cAMP/PKA/CREb signalling pathway partiality. Therefore, EA may be a pivotal therapy on chronic pain induced by pain.
Part 2: Strong Manual Acupuncture simulation of (Huantiao) Reduces Pain Induced Anxiety and p-ERK in the ACC
sMA Stimulation may relieve both mechanical hyperalgesia and pain-induced anxiety in a rat model of neuropathic pain, While moderate MA only reduces anxiety and EA only alleviates mechanical hypersensitivity. We propose that sMA could be a two dimension of pain. The Different acupuncture stimulation of pain. The Effect of Defferent acupuncture stimulation on anxiety like behaviour may arise from the regulation of p-ERK in ACC neurons.