Paul Chapple was awarded a PhD by University College London (UCL) in 1997, this investigated the Hsp70 molecular chaperone system in a marine organism. He then worked in the laboratory of Professor Michael Cheetham at the UCL Institute of Ophthalmology, where he researched the cell biology of chaperone proteins involved in neurodegeneration and blindness. In 2004 he moved to the Institute of Psychiatry to work with Dr Jean-Marc Gallo on the Alzheimer’s protein Tau. He started his own research group at Barts and The London School of Medicine in 2006 and was made Professor in 2014. His research investigates how chaperone systems are specialised in different cell types and organelles, with a focus on human disease.