Title : Mortality trends and disparities in hypertensive patients with Parkinson’s disease in the United States: (1999–2020) A CDC wonder Study
Abstract:
Background: Hypertension and Parkinson's disease (PD) are two of the most common chronic conditions in aging populations, posing a compounded risk when coexisting, significantly increasing mortality. Despite this intersection, research exploring the combined burden remains limited. This study aims to assess mortality disparities by race, gender, and urbanization in individuals with both hypertension and PD in the United States.
Methods: Using the CDC Wonder (Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiological Research) database, Mortality data were assessed from 1999 to 2020 for individuals with both Hypertension and PD, as identified through the(ICD-10) codes. The Multiple Cause-of-Death Public Use file was used to extract age-adjusted mortality rates (AAMRs) per 10,000 population. Trend analysis and Annual Percentage Changes (APCs) were evaluated using the Jointpoint regression Program (Joinpoint V 4.9.0.0) with 95% Confidence Interval(Cl).
Results: Between 1999 and 2020, a total of 116,821 deaths occurred among the population aged ≥ 25 years. The AAMR increased from 0.09 in 1999 to 0.197 in 2001(APC:44.95. 95%Cl:11.2822-88.8125) followed by a gradual increase to 0.268 in 2018 (APC:0.69 ;95%Cl: -0.048-1.424), and another increase to 0.391 in 2020 (APC:20.479;95%Cl:4.2153-39.2822). Men had consistently higher AAMR than women from 1999 (AAMR Men:0.247 vs Women:0.078) to 2020 (AAMR Men:0.532 vs Women:0.268). Whites had the highest overall AAMR, followed by Asian or Pacific Islander, Black or African American, American Indian or Alaska Native.AAMR also varied substantially by region. The Census region Midwest had the highest overall AAMR, followed by the West, South, and Northeast, and nonmetropolitan areas had higher AAMR (0.339) than metropolitan areas (0.247).
Conclusions: Coexisting HTN and PD mortality rates have steadily increased since 1999. The highest AAMRs were observed amongst White adults and men, and among patients living in the Midwest and the nonmetropolitan United States. Targeted strategies are needed to prevent and treat HTN-PD and to curb increasing levels of mortality.
