Title : Brain death reversal by intrathecal Sodium Nitro Prusside (SNP) superfusion in brain death patient - the 10,000-fold effect
Abstract:
Primary or secondary brain death is accompanied with vasospasm of the perforators thus decreasing blood supply in turn it causes absence of brain function. The perforators are having Nitric Oxide Synthetase which is present at the outer border or the adventitial side on which sodium nitroprusside (SNP) acts, causing release of Nitric Oxide which vasodilates the perforators causing gush of blood thus reverting the brain’s function and the effect of retrograde transmission, is mediated by NO's action on haem group of the NO receptor at postsynaptic membrane. This affinity of haem for NO is >10,000 affinity then affinity of hemoglobin for oxygen of blood (THE 10,000 FOLD EFFECT). Thereby we get such a prompt response.
Objective: To study the effect of 10000-FOLD EFFECT BY ITSNP in cases of brain death. SUMMARY OF BACKGROUND DATA. In brain death cases we only think for various transplantations but this study being a pilot study reverses some criteria of brain death by vasodilating the arteriolar perforators.
Methods: 35-year-old male, who became brain death after head injury and has not shown any signs of improvement after every maneuver for 6 hours, a single superfusion done by SNP via transoptic canal route for quadrigeminal cistern and cisternal puncture for IV ventricular with SNP done.
