Toshiki Mizuno, MD, PhD is a professor in Department of Neurology, KyotoPrefectural University of Medicine (Kyoto, Japan). I work for theInternalmedicine as an assistant editor. My major interests are hereditary cerebral small vessel disease, including CADASIL and CARASIL, andvascular dementia. I reported several interesting articles about clinical and genetic study of CADASIL and CARASIL. I’m also interested in the pathomechanism of neurodegenerative disease and to develop a new therapy for neurodegenerative disease using by cellular model and drosophila model.